Skip to content
  • About
  • Contact
  • Contribute
  • Book
  • Careers
  • Podcast
  • Recommended
  • Speaking
  • All
  • Physician
  • Practice
  • Policy
  • Finance
  • Conditions
  • .edu
  • Patient
  • Meds
  • Tech
  • Social
  • Video
    • All
    • Physician
    • Practice
    • Policy
    • Finance
    • Conditions
    • .edu
    • Patient
    • Meds
    • Tech
    • Social
    • Video
    • About
    • Contact
    • Contribute
    • Book
    • Careers
    • Podcast
    • Recommended
    • Speaking

A doctor’s perspective on blood cancer

John Pagel, MD, PhD & The Podcast by KevinMD
Podcast
November 15, 2023
Share
Tweet
Share
YouTube video

This article is sponsored by Loxo@Lilly, the oncology unit of Eli Lilly and Company.

In this special sponsored episode from Loxo@Lilly, I’m joined by Dr. John Pagel, senior vice president of clinical development and global head of hematology at Loxo@Lilly, to discuss blood cancer — what it is, advancements in research and treatment, and his experience in the field.

There are an estimated 1.5 million people in the U.S. living with leukemia and lymphoma, which are types of blood cancer.

In leukemia and lymphoma, white blood cells behave abnormally, and the maturity of these cells determines the type of disease. Abnormalities in immature white blood cells cause leukemia, and abnormalities in mature white blood cells cause lymphoma.

“Somewhere in that process of cell maturation, something can go wrong,” Dr. Pagel says. “They start making too many of themselves. I always think of this like when those white stormtroopers in Star Wars all march.”

Mantle cell lymphoma

There are close to 80 subtypes of leukemia and lymphoma. Mantle cell lymphoma (MCL) is a form of non-Hodgkin lymphoma that arises from a type of white blood cell called B lymphocytes. It is a rare blood cancer that affects the lymphatic system, which helps protect the body against infection and disease.

“Mantle cell lymphoma is one of the more interesting subtypes of non-Hodgkin lymphoma that we address and think about,” Dr. Pagel says. “It has often behaved very aggressively. It is true that people often get chemotherapy for this lymphoma early on, and they get to remission, and they might do well, but they typically will relapse.”

Because relapse is almost universal for people with MCL, many patients will require several lines of treatment. Dr. Pagel says that fortunately, providers now have “a lot of arrows in our quiver of tools” to manage MCL due to recent advancements in research.

There are various approaches to treating MCL, including immunomodulatory and cellular therapies. Inhibition of Bruton tyrosine kinase (BTK), an enzyme that is essential for the normal lifespan of a white blood cell and critically important for the survival of cancerous cells, is also an option. In simplified terms, when cancerous cells grow and divide in MCL, Dr. Pagel says, it is like a light switch has been turned on that won’t turn off. But inhibiting BTK, that critical protein, is one way to address that stuck light switch.

Challenges — and rewards

Although the MCL treatment landscape has grown in recent years, there are still challenges that physicians face in treating and researching this disease and other blood cancers.

Dr. Pagel says that when treating patients, the biggest problem is getting the right therapy to the right person at the right time — so it is critical that patients speak up and find a physician they trust and respect.

“Patients need to be their own best advocate,” Dr. Pagel says. “Do your research, look at your options, talk to your doctor, ask hard questions.”

In terms of hurdles in blood cancer research, Dr. Pagel says that the development of novel therapies can be extremely challenging.

“This process takes a lot of time,” Dr. Pagel says. “Time from discovery of a drug to approval and on the market can take a good decade depending on the drug and depending on the disease.”

Despite the obstacles Dr. Pagel has witnessed in addressing blood cancers, he says he has been lucky to also experience positives over his 25-year career as a physician and researcher, including the special relationships and impact he has been able to have with patients facing life-threatening illnesses.

“People will often ask, ‘How could you go into this field? It’s so depressing, and it’s hard.’ It’s actually completely the opposite,” Dr. Pagel says. “This profession has allowed me to help patients at a level that is really hard to find in any other profession. I’m super lucky and fortunate to have had that kind of opportunity to do that.”

John Pagel is a hematology-oncology physician and senior vice president of clinical development and global head of hematology, Loxo@Lilly.

VISIT SPONSOR → https://www.loxooncology.com/

SUBSCRIBE TO THE PODCAST → https://kevinmd.com/podcast

RATE AND REVIEW → https://kevinmd.com/rate

FOLLOW ON INSTAGRAM → https://www.instagram.com/kevinphomd

FOLLOW ON TIKTOK → https://www.tiktok.com/@kevinphomd

Prev

Bridging law and medicine [PODCAST]

November 14, 2023 Kevin 0
…
Next

Understanding and addressing intimate partner violence in health care

November 15, 2023 Kevin 0
…

Tagged as: Oncology/Hematology

Post navigation

< Previous Post
Bridging law and medicine [PODCAST]
Next Post >
Understanding and addressing intimate partner violence in health care

ADVERTISEMENT

More by John Pagel, MD, PhD & The Podcast by KevinMD

  • Beyond burnout: Understanding the triangle of exhaustion [PODCAST]

    The Podcast by KevinMD
  • Why ADHD in women requires a new approach [PODCAST]

    The Podcast by KevinMD
  • Why point-of-care ultrasound belongs in every emergency department triage [PODCAST]

    The Podcast by KevinMD

Related Posts

  • Cancer patients who want to take unproven supplements

    Marc Braunstein, MD, PhD
  • Is social media a friend or foe of science?

    Michael Joyce, MD
  • Including the patient perspective on tumor boards

    Don S. Dizon, MD
  • Hormone replacement therapy is still linked to cancer

    Martha Rosenberg
  • A chance encounter in Chicago: lessons in compassionate medicine

    Emily S. Hagen, MD
  • We have a shot at preventing cervical cancer

    Lisa N. Abaid, MD, MPH

More in Podcast

  • Beyond burnout: Understanding the triangle of exhaustion [PODCAST]

    The Podcast by KevinMD
  • Why ADHD in women requires a new approach [PODCAST]

    The Podcast by KevinMD
  • Why point-of-care ultrasound belongs in every emergency department triage [PODCAST]

    The Podcast by KevinMD
  • Why financial planning is a critical tool for physician well-being [PODCAST]

    The Podcast by KevinMD
  • Why the U.S. mental health care system is failing and how to fix it [PODCAST]

    The Podcast by KevinMD
  • From Founding Fathers to modern battles: physician activism in a politicized era [PODCAST]

    The Podcast by KevinMD

More in Sponsored

  • Expert Q&A: Dr. Jared Pelo, ambient clinical pioneer, explains how Dragon Copilot helps clinicians deliver better care

    Jared Pelo, MD & Microsoft & Nuance Communications
  • Disability insurance done right: the financial lifeline every physician needs

    The Podcast by KevinMD
  • The buzz around GSI disability insurance for residents: Why it’s gaining popularity and how to take advantage

    Set for Life Insurance
  • Why your disability insurance agent might not offer the most optimized policy

    Set for Life Insurance
  • Patient safety in focus: Helping to address risk factors associated with non-ventilator hospital-acquired pneumonia

    Stryker Oral Care & The Podcast by KevinMD
  • Strategies for patient-centered and employee-focused care

    NRC Health & The Podcast by KevinMD
  • Most Popular

  • Past Week

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • How President Biden’s cognitive health shapes political and legal trust

      Muhamad Aly Rifai, MD | Conditions
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • America’s ER crisis: Why the system is collapsing from within

      Kristen Cline, BSN, RN | Conditions
    • Why timing, not surgery, determines patient survival

      Michael Karch, MD | Conditions
    • How early meetings and after-hours events penalize physician-mothers

      Samira Jeimy, MD, PhD and Menaka Pai, MD | Physician
  • Past 6 Months

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • How President Biden’s cognitive health shapes political and legal trust

      Muhamad Aly Rifai, MD | Conditions
    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • The hidden health risks in the One Big Beautiful Bill Act

      Trevor Lyford, MPH | Policy
  • Recent Posts

    • Beyond burnout: Understanding the triangle of exhaustion [PODCAST]

      The Podcast by KevinMD | Podcast
    • Facing terminal cancer as a doctor and mother

      Kelly Curtin-Hallinan, DO | Conditions
    • Online eye exams spark legal battle over health care access

      Joshua Windham, JD and Daryl James | Policy
    • FDA delays could end vital treatment for rare disease patients

      G. van Londen, MD | Meds
    • Pharmacists are key to expanding Medicaid access to digital therapeutics

      Amanda Matter | Meds
    • Why ADHD in women requires a new approach [PODCAST]

      The Podcast by KevinMD | Podcast

Subscribe to KevinMD and never miss a story!

Get free updates delivered free to your inbox.


Find jobs at
Careers by KevinMD.com

Search thousands of physician, PA, NP, and CRNA jobs now.

Learn more

Leave a Comment

Founded in 2004 by Kevin Pho, MD, KevinMD.com is the web’s leading platform where physicians, advanced practitioners, nurses, medical students, and patients share their insight and tell their stories.

Social

  • Like on Facebook
  • Follow on Twitter
  • Connect on Linkedin
  • Subscribe on Youtube
  • Instagram
  • Most Popular

  • Past Week

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • How President Biden’s cognitive health shapes political and legal trust

      Muhamad Aly Rifai, MD | Conditions
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • America’s ER crisis: Why the system is collapsing from within

      Kristen Cline, BSN, RN | Conditions
    • Why timing, not surgery, determines patient survival

      Michael Karch, MD | Conditions
    • How early meetings and after-hours events penalize physician-mothers

      Samira Jeimy, MD, PhD and Menaka Pai, MD | Physician
  • Past 6 Months

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • How President Biden’s cognitive health shapes political and legal trust

      Muhamad Aly Rifai, MD | Conditions
    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • The hidden health risks in the One Big Beautiful Bill Act

      Trevor Lyford, MPH | Policy
  • Recent Posts

    • Beyond burnout: Understanding the triangle of exhaustion [PODCAST]

      The Podcast by KevinMD | Podcast
    • Facing terminal cancer as a doctor and mother

      Kelly Curtin-Hallinan, DO | Conditions
    • Online eye exams spark legal battle over health care access

      Joshua Windham, JD and Daryl James | Policy
    • FDA delays could end vital treatment for rare disease patients

      G. van Londen, MD | Meds
    • Pharmacists are key to expanding Medicaid access to digital therapeutics

      Amanda Matter | Meds
    • Why ADHD in women requires a new approach [PODCAST]

      The Podcast by KevinMD | Podcast

MedPage Today Professional

An Everyday Health Property Medpage Today
  • Terms of Use | Disclaimer
  • Privacy Policy
  • DMCA Policy
All Content © KevinMD, LLC
Site by Outthink Group

Leave a Comment

Comments are moderated before they are published. Please read the comment policy.

Loading Comments...