Skip to content
  • About
  • Contact
  • Contribute
  • Book
  • Careers
  • Podcast
  • Recommended
  • Speaking
  • All
  • Physician
  • Practice
  • Policy
  • Finance
  • Conditions
  • .edu
  • Patient
  • Meds
  • Tech
  • Social
  • Video
    • All
    • Physician
    • Practice
    • Policy
    • Finance
    • Conditions
    • .edu
    • Patient
    • Meds
    • Tech
    • Social
    • Video
    • About
    • Contact
    • Contribute
    • Book
    • Careers
    • Podcast
    • Recommended
    • Speaking

Drugs used to treat Parkinson’s disease can worsen impulsivity

William R. Yates, MD
Meds
October 19, 2010
Share
Tweet
Share

Parkinson’s disease (PD) commonly includes a variety of behavioral disturbances related to impulsivity.  Impulse control problems noted in PD includes hypersexuality, compulsive shopping, compulsive eating and pathological gambling.

These behavioral problems may be related to the pathophysiology of Parkinson’s disease.  However, drugs commonly used in Parkinson’s disease appear to increase the risk for impulsive behavioral problems.

Clinicians face a dilemma in drug-induced behavioral disturbances.  The drugs that may be effective for treating the motor symptoms may be causing behavioral problems.  Stop the drug and the behavioral symptoms improve but the motor symptoms return.

Dysregulation in brain glutamate has been hypothesized to contribute to dyskinesias and behavioral problems in PD.  Dopaminergic drugs may alter glutamate regulation as well as sensitizing dopamine and NMDA glutamtergic receptors.

Thomas and colleagues from Italy, recently published a clinical trial examining the effect of the antiglutamatergic drug amantadine for pathological gambling in PD.  The key elements of the study design included:

  • 17 subjects with PD
  • Double-blind crossover study
  • Amantadine 200 mg/day vs placebo (50 mg twice daily for two days then 100 mg twice daily)
  • Outcome variables: Yale-Brown Obsessive Compulsive Scale for Pathological Gambling, Gambling-Symptom Assessment Scale, South Oaks Gambling Screen, time and money spent gambling

All the subjects were gambling by purchasing scratch off lottery tickets and about a third also were gambling using slot machines.  Before the intervention, they were losing 2% of their salary per gambling day.

Amantadine treatment produced a significant reduction in the primary psychometric measures and in time and money spent gambling.  The effect appeared within two to three days of initiation.

Amantadine treatment resulted in five drop-outs during the study.  Main adverse effects included: insomnia, visual hallucination, orthostatic hypotension and confusion.  It appears that amantadine may not be tolerated by many with PD and this may limit its use.

This study needs replication before changing clinical practice approaches.  The study does highlight the potential role of glutamatergic drugs in impulse control disorders including pathological gambling.

Amantadine may be a promising research drug for clinical trials in pathological gambling in younger populations without PD.

William Yates is a family physician who blogs at
Brain Posts.

Submit a guest post and be heard.

Prev

Technology can help your aging parents

October 19, 2010 Kevin 5
…
Next

How the Affordable Care Act helps Medicare

October 19, 2010 Kevin 10
…

Tagged as: Medications

Post navigation

< Previous Post
Technology can help your aging parents
Next Post >
How the Affordable Care Act helps Medicare

ADVERTISEMENT

More by William R. Yates, MD

  • a desk with keyboard and ipad with the kevinmd logo

    Exercise can help treat fibromyalgia

    William R. Yates, MD
  • a desk with keyboard and ipad with the kevinmd logo

    How autism affects social interaction

    William R. Yates, MD
  • a desk with keyboard and ipad with the kevinmd logo

    Google affects how clinicians and the public collect diagnostic information

    William R. Yates, MD

More in Meds

  • Every medication error is a system failure, not a personal flaw

    Muhammad Abdullah Khan
  • Why kratom addiction is the next public health crisis

    Muhamad Aly Rifai, MD
  • FDA delays could end vital treatment for rare disease patients

    GJ van Londen, MD
  • Pharmacists are key to expanding Medicaid access to digital therapeutics

    Amanda Matter
  • How medicine repurposing enables value-based pain management and insomnia therapy

    Olumuyiwa Bamgbade, MD
  • Forced voicemail and diagnosis codes are endangering patient access to medications

    Arthur Lazarus, MD, MBA
  • Most Popular

  • Past Week

    • How a doctor defied a hurricane to save a life

      Dharam Persaud-Sharma, MD, PhD | Physician
    • Why primary care needs better dermatology training

      Alex Siauw | Conditions
    • Guilty until proven innocent? My experience with a state medical board.

      Jeffrey Hatef, Jr., MD | Physician
    • Why physician strikes are a form of hospice

      Patrick Hudson, MD | Physician
    • Why medical notes have become billing scripts instead of patient stories

      Sriman Swarup, MD, MBA | Tech
    • Federal shakeup of vaccine policy and the battle for public trust [PODCAST]

      American College of Physicians & The Podcast by KevinMD | Podcast
  • Past 6 Months

    • Why transgender health care needs urgent reform and inclusive practices

      Angela Rodriguez, MD | Conditions
    • COVID-19 was real: a doctor’s frontline account

      Randall S. Fong, MD | Conditions
    • Why primary care doctors are drowning in debt despite saving lives

      John Wei, MD | Physician
    • New student loan caps could shut low-income students out of medicine

      Tom Phan, MD | Physician
    • Confessions of a lipidologist in recovery: the infection we’ve ignored for 40 years

      Larry Kaskel, MD | Conditions
    • mRNA post vaccination syndrome: Is it real?

      Harry Oken, MD | Conditions
  • Recent Posts

    • Federal shakeup of vaccine policy and the battle for public trust [PODCAST]

      American College of Physicians & The Podcast by KevinMD | Podcast
    • Why clinicians must lead health care tech innovation

      Kimberly Smith, RN | Tech
    • The truth about sun exposure: What dermatologists want you to know

      Shafat Hassan, MD, PhD, MPH | Conditions
    • Learning medicine in the age of AI: Why future doctors need digital fluency

      Kelly D. França | Education
    • How a South Asian nurse challenged stereotypes in health care

      Viksit Bali, RN | Conditions
    • Doctors reclaiming their humanity in a broken system [PODCAST]

      The Podcast by KevinMD | Podcast

Subscribe to KevinMD and never miss a story!

Get free updates delivered free to your inbox.


Find jobs at
Careers by KevinMD.com

Search thousands of physician, PA, NP, and CRNA jobs now.

Learn more

Leave a Comment

Founded in 2004 by Kevin Pho, MD, KevinMD.com is the web’s leading platform where physicians, advanced practitioners, nurses, medical students, and patients share their insight and tell their stories.

Social

  • Like on Facebook
  • Follow on Twitter
  • Connect on Linkedin
  • Subscribe on Youtube
  • Instagram

ADVERTISEMENT

ADVERTISEMENT

  • Most Popular

  • Past Week

    • How a doctor defied a hurricane to save a life

      Dharam Persaud-Sharma, MD, PhD | Physician
    • Why primary care needs better dermatology training

      Alex Siauw | Conditions
    • Guilty until proven innocent? My experience with a state medical board.

      Jeffrey Hatef, Jr., MD | Physician
    • Why physician strikes are a form of hospice

      Patrick Hudson, MD | Physician
    • Why medical notes have become billing scripts instead of patient stories

      Sriman Swarup, MD, MBA | Tech
    • Federal shakeup of vaccine policy and the battle for public trust [PODCAST]

      American College of Physicians & The Podcast by KevinMD | Podcast
  • Past 6 Months

    • Why transgender health care needs urgent reform and inclusive practices

      Angela Rodriguez, MD | Conditions
    • COVID-19 was real: a doctor’s frontline account

      Randall S. Fong, MD | Conditions
    • Why primary care doctors are drowning in debt despite saving lives

      John Wei, MD | Physician
    • New student loan caps could shut low-income students out of medicine

      Tom Phan, MD | Physician
    • Confessions of a lipidologist in recovery: the infection we’ve ignored for 40 years

      Larry Kaskel, MD | Conditions
    • mRNA post vaccination syndrome: Is it real?

      Harry Oken, MD | Conditions
  • Recent Posts

    • Federal shakeup of vaccine policy and the battle for public trust [PODCAST]

      American College of Physicians & The Podcast by KevinMD | Podcast
    • Why clinicians must lead health care tech innovation

      Kimberly Smith, RN | Tech
    • The truth about sun exposure: What dermatologists want you to know

      Shafat Hassan, MD, PhD, MPH | Conditions
    • Learning medicine in the age of AI: Why future doctors need digital fluency

      Kelly D. França | Education
    • How a South Asian nurse challenged stereotypes in health care

      Viksit Bali, RN | Conditions
    • Doctors reclaiming their humanity in a broken system [PODCAST]

      The Podcast by KevinMD | Podcast

MedPage Today Professional

An Everyday Health Property Medpage Today
  • Terms of Use | Disclaimer
  • Privacy Policy
  • DMCA Policy
All Content © KevinMD, LLC
Site by Outthink Group

Leave a Comment

Comments are moderated before they are published. Please read the comment policy.

Loading Comments...