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Ketamine therapy for chronic pain and substance misuse

Olumuyiwa Bamgbade, MD
Meds
March 13, 2026
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Health care works best when it solves real problems in real lives. That is why recent research on ketamine therapy for chronic pain deserves attention. The peer-reviewed study looked at 20 adults living with chronic pain who also struggled with substance misuse. The results suggest that carefully designed pain treatment may help more than pain alone. It may also improve mood and support recovery from substance misuse. In a time of ongoing substance misuse, overdose deaths, and rising mental health needs, that matters a great deal. Many people do not misuse substances because they want to cause harm. Many are trying to survive pain, emotional distress, poor sleep, trauma, or loss of function. Chronic pain can be isolating and exhausting. Some people begin with prescribed medication. Others turn to nonmedical substances when they feel desperate. Either way, the result can become a dangerous cycle. Pain worsens stress. Stress worsens substance use. Substance use then worsens health and stability. This is why a one-dimensional approach often fails.

The research offers a different lens. It suggests that ketamine-based treatment, used as part of a clinical pain program, may help break that cycle. Patients in the study showed improvement in pain, mood, and dependence scores. That matters because health care should aim to improve the whole person. A person is not just a pain score. A person is also their sleep, mood, safety, mobility, relationships, and ability to function in daily life. This is the heart of value-based care. Value-based care is not about doing more. It is about doing what works. It rewards care that improves outcomes people can feel and measure. When a treatment helps reduce pain and supports better mental health and lower substance dependence, the ripple effects can be large. Patients may need fewer crisis visits. Families may face less fear and burnout. Communities may see fewer overdoses and fewer drug-related emergencies. Health systems may spend money more wisely.

The clinical study also strengthens the case for integrated pain care and substance misuse services. People with both pain and substance misuse should not be forced to bounce between disconnected providers. They need one coordinated care pathway. That pathway should include physicians, pharmacists, counselors, nurses, and other professionals working together. Physicians diagnose, monitor, and lead medical treatment. Pharmacists improve medication safety and help reduce harmful drug interactions. Counselors support coping, recovery, relapse prevention, and emotional healing. Physiotherapists, psychologists, social workers, and community partners can add even more support. This type of interdisciplinary collaboration is not a luxury. It is a necessity. Substance misuse epidemics are complex. Chronic pain is complex. Human lives are complex, too. No single profession can solve it all alone. When stakeholders work together, patients get safer, more humane, and more effective care.

This clinical study is modest in size, so larger studies are still needed. Still, its message is powerful. We should stop separating pain care from substance misuse care. Better care connects them. Better systems support teamwork. Better outcomes follow. That is the kind of health care people deserve, especially in the middle of a substance misuse epidemic.

Olumuyiwa Bamgbade is an accomplished health care leader with a strong focus on value-based health care delivery. A specialist physician with extensive training across Nigeria, the United Kingdom, the United States, and South Korea, Dr. Bamgbade brings a global perspective to clinical practice and health systems innovation.

He serves as an adjunct professor at academic institutions across Africa, Europe, and North America and has published 45 peer-reviewed scientific papers in PubMed-indexed journals. His global research collaborations span more than 20 countries, including Nigeria, Australia, Iran, Mozambique, Rwanda, Kenya, Armenia, South Africa, the U.K., China, Ethiopia, and the U.S.

Dr. Bamgbade is the director of Salem Pain Clinic in Surrey, British Columbia, Canada—a specialist and research-focused clinic. His work at the clinic centers on pain management, health equity, injury rehabilitation, neuropathy, insomnia, societal safety, substance misuse, medical sociology, public health, medicolegal science, and perioperative care.

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