Hana Kahleova, MD, PhD, MBA
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Latest articles
Conditions and diseases
Most of us have a well-rehearsed speech for patients with elevated blood sugar. We talk about the heart. The kidneys. The eyes. The feet. We walk through the whole organ-by-organ checklist a glucose reading can quietly damage over the years.…
Most of us have a well-rehearsed speech for patients with elevated blood sugar. We talk about the heart. The kidneys. The eyes. The feet. We walk through the whole organ-by-organ checklist a glucose reading can quietly damage over the years. What most of us, myself included, haven’t been saying nearly often enough is anything about the brain, and a study published this summer in Molecular Psychiatry is a good reason …
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Blood sugar and brain aging start long before diabetes
Drugs and prescribing
I have some version of the same conversation every week now. A patient is starting semaglutide or tirzepatide, and partway through the visit they ask the question I suspect most of us are hearing constantly: What happens if I ever…
I have some version of the same conversation every week now. A patient is starting semaglutide or tirzepatide, and partway through the visit they ask the question I suspect most of us are hearing constantly: What happens if I ever stop?
For a while I gave the honest-but-incomplete answer, that we’d cross that bridge when we got there. I don’t anymore, because I think the real answer has less to do …
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GLP-1 weight regain: We are funding the wrong half
Conditions and diseases
A few years ago, in a clinical trial my colleagues and I ran, something happened that I still find myself thinking about. We asked postmenopausal women who were having frequent, disruptive hot flashes to change one thing: their diet. They…
A few years ago, in a clinical trial my colleagues and I ran, something happened that I still find myself thinking about. We asked postmenopausal women who were having frequent, disruptive hot flashes to change one thing: their diet. They shifted to a low-fat, plant-based pattern with a serving of soybeans each day. We weren’t testing a drug or a hormone. We were testing food.
After 12 weeks, moderate-to-severe hot flashes …
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What menopause reveals about the body as a network
Conditions and diseases
A patient sat across from me not long ago and said, "I feel like I'm doing everything right, and still failing." She had lost weight. She was taking her medications exactly as prescribed. She had reworked her diet along the…
A patient sat across from me not long ago and said, “I feel like I’m doing everything right, and still failing.” She had lost weight. She was taking her medications exactly as prescribed. She had reworked her diet along the lines we’d discussed. Yet her glucose readings remained stubbornly elevated.
I’ve heard some version of that sentence throughout my career as a physician and clinical researcher studying metabolism and diabetes. This …
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The link between light and blood sugar control
Conditions and diseases
If GLP-1 drugs are the breakthrough of this decade, diet may be the most overlooked way to enhance their effect. These medications have transformed the treatment of obesity and type 2 diabetes, delivering levels of weight loss and glycemic control…
If GLP-1 drugs are the breakthrough of this decade, diet may be the most overlooked way to enhance their effect.
These medications have transformed the treatment of obesity and type 2 diabetes, delivering levels of weight loss and glycemic control that were once unimaginable. They are, without question, one of the most important pharmacologic advances in modern medicine.
But amid this progress, we are overlooking a simpler and more fundamental question. Have …
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Diet and GLP-1 drugs work better together
Conditions and diseases
For more than a decade, the phrase "ultra-processed food" has functioned as nutritional shorthand for danger, a dietary villain blamed for rising rates of obesity, diabetes, and heart disease. The public message has been simple: If it is ultra-processed, avoid…
For more than a decade, the phrase “ultra-processed food” has functioned as nutritional shorthand for danger, a dietary villain blamed for rising rates of obesity, diabetes, and heart disease. The public message has been simple: If it is ultra-processed, avoid it. But science is rarely that simple.
My colleagues and I recently reviewed the growing body of research examining ultra-processed foods, not as a single monolithic category, but as distinct …
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Rethinking nutrition policy on ultra-processed food
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