Hana Kahleova is an endocrinologist.

GLP-1 weight regain: We are funding the wrong half

Medications
September 1, 2026

I have some version of the same conversation every week now. A patient is starting semaglutide or tirzepatide, and partway through the visit they ask the question I suspect most of us are hearing constantly: What happens if I ever stop?

For a while I gave the honest-but-incomplete answer, that we’d cross that bridge when we got there. I don’t anymore, because I think the real answer has less to do …

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GLP-1 weight regain: We are funding the wrong half

What menopause reveals about the body as a network

Conditions and Diseases
August 17, 2026

A few years ago, in a clinical trial my colleagues and I ran, something happened that I still find myself thinking about. We asked postmenopausal women who were having frequent, disruptive hot flashes to change one thing: their diet. They shifted to a low-fat, plant-based pattern with a serving of soybeans each day. We weren’t testing a drug or a hormone. We were testing food.

After 12 weeks, moderate-to-severe hot flashes …

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What menopause reveals about the body as a network

The link between light and blood sugar control

Conditions and Diseases
August 10, 2026

A patient sat across from me not long ago and said, “I feel like I’m doing everything right, and still failing.” She had lost weight. She was taking her medications exactly as prescribed. She had reworked her diet along the lines we’d discussed. Yet her glucose readings remained stubbornly elevated.

I’ve heard some version of that sentence throughout my career as a physician and clinical researcher studying metabolism and diabetes. This …

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The link between light and blood sugar control

Diet and GLP-1 drugs work better together

Conditions and Diseases
June 3, 2026

If GLP-1 drugs are the breakthrough of this decade, diet may be the most overlooked way to enhance their effect.

These medications have transformed the treatment of obesity and type 2 diabetes, delivering levels of weight loss and glycemic control that were once unimaginable. They are, without question, one of the most important pharmacologic advances in modern medicine.

But amid this progress, we are overlooking a simpler and more fundamental question. Have …

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Diet and GLP-1 drugs work better together

Rethinking nutrition policy on ultra-processed food

Conditions and Diseases
April 24, 2026

For more than a decade, the phrase “ultra-processed food” has functioned as nutritional shorthand for danger, a dietary villain blamed for rising rates of obesity, diabetes, and heart disease. The public message has been simple: If it is ultra-processed, avoid it. But science is rarely that simple.

My colleagues and I recently reviewed the growing body of research examining ultra-processed foods, not as a single monolithic category, but as distinct …

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Rethinking nutrition policy on ultra-processed food