Skip to content
  • About
  • Contact
  • Contribute
  • Book
  • Careers
  • Podcast
  • Recommended
  • Speaking
  • All
  • Physician
  • Practice
  • Policy
  • Finance
  • Conditions
  • .edu
  • Patient
  • Meds
  • Tech
  • Social
  • Video
    • All
    • Physician
    • Practice
    • Policy
    • Finance
    • Conditions
    • .edu
    • Patient
    • Meds
    • Tech
    • Social
    • Video
    • About
    • Contact
    • Contribute
    • Book
    • Careers
    • Podcast
    • Recommended
    • Speaking

Kissing disease’s link to multiple sclerosis

Hoag Memorial Hospital Presbyterian
Conditions
February 21, 2022
Share
Tweet
Share

In recent decades, mounting evidence has suggested the Epstein-Barr virus (EBV), a ubiquitous member of the herpes family that causes infectious mononucleosis (a.k.a. the “kissing disease”), can cause multiple sclerosis (MS). Last month, a study published in the journal Science went even further, citing EBV infection as likely the leading cause of MS. It is a compelling connection that begs many questions. For example, if someone has had mono – and 90 percent of U.S. adults have been exposed during their lifetime – should they worry about developing MS? Can they do anything to stop it? If we find a vaccine for EBV, can we prevent MS and possibly cure it? And what does this example of a viral link to an autoimmune disease tell us about potential future risks from COVID-19 infection? All are important questions for medical researchers, clinicians and, ultimately, patients and our society.

The suspected link between nervous system diseases and viruses is not new. In fact, many autoimmune diseases are thought to originate from something called “antigen mimicry.” Think of it as if the disease-causing agents, or “bad guys,” are wearing a kind of antigen “jacket.” Immune cells, the “good guys,” look for bad guys wearing this jacket to detect and destroy. In some instances, the good guys mistake one jacket for another and attack in a form of friendly fire. With MS, it’s thought the brain’s white matter mimics a bad-guy antigen.

Encephalitis lethargica or “sleepy disease,” first described in 1917, was followed by a Parkinson’s-like condition that was linked to the 1918 influenza pandemic. This story was told in the Oliver Sacks book Awakenings, which also inspired an iconic movie starring Robin Williams. Both tell the frightening story of how a simple viral infection “just the flu” years later triggered a crippling, relentless, and rare neurological disease.

As a neuroimmunologist specializing in MS and involved in post-COVID neurological complications research and treatment, I cannot help but wonder what we might see years after the current pandemic has ended. We are already seeing long-term immune reactions in people who have been infected. With one variant or another infecting most of humanity, will we see other unusual autoimmune diseases emerge decades from now? Another concern is that the COVID-19 virus might make old, “dormant” infections active again. EBV is one virus that has reportedly become re-activated during COVID-19 infection, as has herpes zoster. Could that potentially increase the risk of MS onset or new attacks?

Currently, there is no cure for MS, which often leads to disability and loss of employment. Until a cure is found, this latest study linking EVB to the disease makes it very plausible that a vaccine against EBV could dramatically reduce the burden of MS on patients and our society. However, we would need everyone to understand the benefit of this effort, and vaccine skepticism would pose a significant challenge.

Clearly, there are many important, unanswered questions and much work to be done. But we now have a clearer picture of where to focus our research efforts. This is positive news for those suffering from MS and, potentially, other autoimmune diseases.

Yasir Jassam is a board-certified neurologist, Hoag Memorial Hospital Presbyterian, Newport Beach, CA.

Image credit: Shutterstock.com

Prev

Who will heal the physician?

February 21, 2022 Kevin 0
…
Next

A milligram of understanding for the vaccine-hesitant [PODCAST]

February 21, 2022 Kevin 0
…

Tagged as: Infectious Disease

Post navigation

< Previous Post
Who will heal the physician?
Next Post >
A milligram of understanding for the vaccine-hesitant [PODCAST]

ADVERTISEMENT

More by Hoag Memorial Hospital Presbyterian

  • Why male fertility needs to be part of every health conversation

    Hoag Memorial Hospital Presbyterian
  • Cancer treatment and sexual health: the conversation we need to have

    Hoag Memorial Hospital Presbyterian
  • How AI is transforming breast cancer detection: a game-changing tool for early diagnosis and personalized care

    Hoag Memorial Hospital Presbyterian

Related Posts

  • Should only infectious disease specialists be allowed to prescribe antibiotics?

    Craig Bowron, MD
  • The culture of perfection in medicine is a disease

    Andy Cruz, MD
  • Chronic disease is making medical education worse

    Jason J. Han, MD
  • There are drawbacks when multiple layers are placed between patient and physician

    Elaine Walizer
  • Is there a link between readmission and a hospital’s non-profit status?

    David Lozar, MD
  • Health care workers should not be targets

    Lori E. Johnson

More in Conditions

  • Healing beyond the surface: Why proper chronic wound care matters

    Alvin May, MD
  • Why specialist pain clinics and addiction treatment services require strong primary care

    Olumuyiwa Bamgbade, MD
  • What a childhood stroke taught me about the future of neurosurgery and the promise of vagus nerve stimulation

    William J. Bannon IV
  • Facing terminal cancer as a doctor and mother

    Kelly Curtin-Hallinan, DO
  • Why doctors must stop ignoring unintentional weight loss in patients with obesity

    Samantha Malley, FNP-C
  • Why hospitals are quietly capping top doctors’ pay

    Dennis Hursh, Esq
  • Most Popular

  • Past Week

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • America’s ER crisis: Why the system is collapsing from within

      Kristen Cline, BSN, RN | Conditions
    • Why timing, not surgery, determines patient survival

      Michael Karch, MD | Conditions
    • How early meetings and after-hours events penalize physician-mothers

      Samira Jeimy, MD, PhD and Menaka Pai, MD | Physician
    • FDA delays could end vital treatment for rare disease patients

      GJ van Londen, MD | Meds
  • Past 6 Months

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • How President Biden’s cognitive health shapes political and legal trust

      Muhamad Aly Rifai, MD | Conditions
    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • Here’s what providers really need in a modern EHR

      Laura Kohlhagen, MD, MBA | Tech
  • Recent Posts

    • Civil discourse as a leadership competency: the case for curiosity in medicine

      All Levels Leadership | Physician
    • Healing beyond the surface: Why proper chronic wound care matters

      Alvin May, MD | Conditions
    • Why specialist pain clinics and addiction treatment services require strong primary care

      Olumuyiwa Bamgbade, MD | Conditions
    • Dear July intern: It’s normal to feel clueless—here’s what matters

      Tomi Mitchell, MD | Education
    • Who gets to be well in America: Immigrant health is on the line

      Joshua Vasquez, MD | Policy
    • When a medical office sublease turns into a legal nightmare

      Ralph Messo, DO | Physician

Subscribe to KevinMD and never miss a story!

Get free updates delivered free to your inbox.


Find jobs at
Careers by KevinMD.com

Search thousands of physician, PA, NP, and CRNA jobs now.

Learn more

Leave a Comment

Founded in 2004 by Kevin Pho, MD, KevinMD.com is the web’s leading platform where physicians, advanced practitioners, nurses, medical students, and patients share their insight and tell their stories.

Social

  • Like on Facebook
  • Follow on Twitter
  • Connect on Linkedin
  • Subscribe on Youtube
  • Instagram

ADVERTISEMENT

  • Most Popular

  • Past Week

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • America’s ER crisis: Why the system is collapsing from within

      Kristen Cline, BSN, RN | Conditions
    • Why timing, not surgery, determines patient survival

      Michael Karch, MD | Conditions
    • How early meetings and after-hours events penalize physician-mothers

      Samira Jeimy, MD, PhD and Menaka Pai, MD | Physician
    • FDA delays could end vital treatment for rare disease patients

      GJ van Londen, MD | Meds
  • Past 6 Months

    • Forced voicemail and diagnosis codes are endangering patient access to medications

      Arthur Lazarus, MD, MBA | Meds
    • How President Biden’s cognitive health shapes political and legal trust

      Muhamad Aly Rifai, MD | Conditions
    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • The One Big Beautiful Bill and the fragile heart of rural health care

      Holland Haynie, MD | Policy
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • Here’s what providers really need in a modern EHR

      Laura Kohlhagen, MD, MBA | Tech
  • Recent Posts

    • Civil discourse as a leadership competency: the case for curiosity in medicine

      All Levels Leadership | Physician
    • Healing beyond the surface: Why proper chronic wound care matters

      Alvin May, MD | Conditions
    • Why specialist pain clinics and addiction treatment services require strong primary care

      Olumuyiwa Bamgbade, MD | Conditions
    • Dear July intern: It’s normal to feel clueless—here’s what matters

      Tomi Mitchell, MD | Education
    • Who gets to be well in America: Immigrant health is on the line

      Joshua Vasquez, MD | Policy
    • When a medical office sublease turns into a legal nightmare

      Ralph Messo, DO | Physician

MedPage Today Professional

An Everyday Health Property Medpage Today
  • Terms of Use | Disclaimer
  • Privacy Policy
  • DMCA Policy
All Content © KevinMD, LLC
Site by Outthink Group

Leave a Comment

Comments are moderated before they are published. Please read the comment policy.

Loading Comments...