Skip to content
  • About
  • Contact
  • Contribute
  • Book
  • Careers
  • Podcast
  • Recommended
  • Speaking
  • All
  • Physician
  • Practice
  • Policy
  • Finance
  • Conditions
  • .edu
  • Patient
  • Meds
  • Tech
  • Social
  • Video
    • All
    • Physician
    • Practice
    • Policy
    • Finance
    • Conditions
    • .edu
    • Patient
    • Meds
    • Tech
    • Social
    • Video
    • About
    • Contact
    • Contribute
    • Book
    • Careers
    • Podcast
    • Recommended
    • Speaking

Should you get a COVID-19 antibody test?

Christine Lau, MD
Conditions
June 28, 2020
Share
Tweet
Share

Antibody testing, also called serological testing, can be used to determine whether an individual is currently infected with COVID-19 or has previously been infected with COVID-19 and recovered. Unlike the molecular testing (PCR tests), which detects the presence of genetic material from the virus from a nasopharyngeal or oropharyngeal swab, these antibody tests identify exposure to SARS-CoV-2 (the virus which causes COVID-19) by looking for antibodies generated by the immune response. Most SARS-CoV-2 antibody tests detect IgM and/or IgG. IgM is the first antibody the body builds when fighting a new infection, and may indicate you are still infected or recently recovered. IgG, on the other hand, takes 7 to 10 days to develop, and indicate you have previously been infected and recovered.

Antibody testing detects the body’s immune response to the infection, rather than detecting the virus itself. As such, there are limitations to the effectiveness of antibody testing in diagnosing COVID-19. At the start of an infection, especially in the first day or two, the body may not have developed sufficient IgM antibodies to be detectable in peripheral blood. Individuals who exhibit very mild to no symptoms, including asymptomatic carriers, may not mount a sufficient immune response to generate detectable levels of antibodies. Furthermore, some individuals who are immunocompromised may not build enough antibodies and therefore lead to false negatives.

Despite these limitations, antibody testing still plays a role in the COVID-19 pandemic. Antibody testing can be useful in screening individuals without symptoms. Many antibody tests are rapid tests, which involves only a fingerstick, and yields results in 10 to 20 minutes. Due to supply limitations and laboratory limitations to the number of molecular tests that can be performed, it would be extremely difficult (if not impossible) to test everyone with the nasopharyngeal or oropharyngeal swab. In addition, the molecular tests only capture whether or not the individual is infected at that current time – the individual can become infected the next day.

Another reason for antibody testing, and perhaps one of the most important reasons, is its use in research and epidemiology – in helping to understand the impact of the virus. By tracking exposure rates to the virus, safety protocols and interventions can be implemented to ensure public health and safety. By tracking an individual’s antibody titers, we can determine how long these antibodies remain in the body and whether or not an individual can build an immunity to the virus. Furthermore, by identifying individuals who have recovered and developed IgG antibodies, we can identify potential plasma donors who may be beneficial in treating other COVID-19 patients.

Molecular and serological testing are different things, and both play crucial roles in battling this pandemic.

Christine Lau is a physician.

Image credit: Shutterstock.com

Prev

The sensory limitation of wearing masks

June 28, 2020 Kevin 1
…
Next

Why do Black Americans have worse COVID outcomes?

June 28, 2020 Kevin 5
…

Tagged as: COVID, Infectious Disease

Post navigation

< Previous Post
The sensory limitation of wearing masks
Next Post >
Why do Black Americans have worse COVID outcomes?

ADVERTISEMENT

More by Christine Lau, MD

  • 4 lessons the pandemic has taught health care

    Christine Lau, MD
  • 6 things people should know about the COVID-19 vaccines

    Christine Lau, MD
  • Be grateful this holiday season

    Christine Lau, MD

Related Posts

  • How to get patients vaccinated against COVID-19 [PODCAST]

    The Podcast by KevinMD
  • COVID-19 divides and conquers

    Michele Luckenbaugh
  • State sanctioned executions in the age of COVID-19

    Kasey Johnson, DO
  • A patient’s COVID-19 reflections

    Michele Luckenbaugh
  • Starting medical school in the midst of COVID-19

    Horacio Romero Castillo
  • COVID-19 shows why we need health insurance

    Jingyi Liu, MD

More in Conditions

  • What Elon Musk and Diddy reveal about the price of power

    Osmund Agbo, MD
  • Understanding depression beyond biology: the power of therapy and meaning

    Maire Daugharty, MD
  • Why medicine must stop worshipping burnout and start valuing humanity

    Sarah White, APRN
  • Why perinatal mental health is the top cause of maternal death in the U.S.

    Sheila Noon
  • A world without vaccines: What history teaches us about public health

    Drew Remignanti, MD, MPH
  • Unraveling the mystery behind one of the most dangerous pregnancy complications: preeclampsia

    Thomas McElrath, MD, PhD and Kara Rood, MD
  • Most Popular

  • Past Week

    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • Here’s what providers really need in a modern EHR

      Laura Kohlhagen, MD, MBA | Tech
    • How New Mexico became a malpractice lawsuit hotspot

      Patrick Hudson, MD | Physician
    • How community paramedicine impacts Indigenous elders

      Noah Weinberg | Conditions
    • Why doctors are reclaiming control from burnout culture

      Maureen Gibbons, MD | Physician
  • Past 6 Months

    • Why tracking cognitive load could save doctors and patients

      Hiba Fatima Hamid | Education
    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • What the world must learn from the life and death of Hind Rajab

      Saba Qaiser, RN | Conditions
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • Here’s what providers really need in a modern EHR

      Laura Kohlhagen, MD, MBA | Tech
    • How medical culture hides burnout in plain sight

      Marco Benítez | Conditions
  • Recent Posts

    • From Founding Fathers to modern battles: physician activism in a politicized era [PODCAST]

      The Podcast by KevinMD | Podcast
    • From stigma to science: Rethinking the U.S. drug scheduling system

      Artin Asadipooya | Meds
    • The gift we keep giving: How medicine demands everything—even our holidays

      Tomi Mitchell, MD | Physician
    • The promise and perils of AI in health care: Why we need better testing standards

      Max Rollwage, PhD | Tech
    • From burnout to balance: a neurosurgeon’s bold career redesign

      Jessie Mahoney, MD | Physician
    • Healing the doctor-patient relationship by attacking administrative inefficiencies

      Allen Fredrickson | Policy

Subscribe to KevinMD and never miss a story!

Get free updates delivered free to your inbox.


Find jobs at
Careers by KevinMD.com

Search thousands of physician, PA, NP, and CRNA jobs now.

Learn more

Leave a Comment

Founded in 2004 by Kevin Pho, MD, KevinMD.com is the web’s leading platform where physicians, advanced practitioners, nurses, medical students, and patients share their insight and tell their stories.

Social

  • Like on Facebook
  • Follow on Twitter
  • Connect on Linkedin
  • Subscribe on Youtube
  • Instagram

ADVERTISEMENT

  • Most Popular

  • Past Week

    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • Here’s what providers really need in a modern EHR

      Laura Kohlhagen, MD, MBA | Tech
    • How New Mexico became a malpractice lawsuit hotspot

      Patrick Hudson, MD | Physician
    • How community paramedicine impacts Indigenous elders

      Noah Weinberg | Conditions
    • Why doctors are reclaiming control from burnout culture

      Maureen Gibbons, MD | Physician
  • Past 6 Months

    • Why tracking cognitive load could save doctors and patients

      Hiba Fatima Hamid | Education
    • Why are medical students turning away from primary care? [PODCAST]

      The Podcast by KevinMD | Podcast
    • What the world must learn from the life and death of Hind Rajab

      Saba Qaiser, RN | Conditions
    • Why “do no harm” might be harming modern medicine

      Sabooh S. Mubbashar, MD | Physician
    • Here’s what providers really need in a modern EHR

      Laura Kohlhagen, MD, MBA | Tech
    • How medical culture hides burnout in plain sight

      Marco Benítez | Conditions
  • Recent Posts

    • From Founding Fathers to modern battles: physician activism in a politicized era [PODCAST]

      The Podcast by KevinMD | Podcast
    • From stigma to science: Rethinking the U.S. drug scheduling system

      Artin Asadipooya | Meds
    • The gift we keep giving: How medicine demands everything—even our holidays

      Tomi Mitchell, MD | Physician
    • The promise and perils of AI in health care: Why we need better testing standards

      Max Rollwage, PhD | Tech
    • From burnout to balance: a neurosurgeon’s bold career redesign

      Jessie Mahoney, MD | Physician
    • Healing the doctor-patient relationship by attacking administrative inefficiencies

      Allen Fredrickson | Policy

MedPage Today Professional

An Everyday Health Property Medpage Today
  • Terms of Use | Disclaimer
  • Privacy Policy
  • DMCA Policy
All Content © KevinMD, LLC
Site by Outthink Group

Leave a Comment

Comments are moderated before they are published. Please read the comment policy.

Loading Comments...