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Understanding why people participate in clinical trials

Pouria Rostamiasrabadi
Education
June 25, 2024
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Clinical research is a cornerstone in advancing medical knowledge and improving patient care. Through rigorous testing and validation of new treatments, medications, and procedures, clinical research drives progress in the health care field. A notable example is the development of the polio vaccine, which underwent extensive clinical trials by Jonas Salk involving approximately 1.6 million children in the United States, Canada, and Finland to ensure its safety and efficacy, ultimately leading to the near-eradication of a once-devastating disease. Central to this process are the volunteers who participate in clinical studies. Their involvement is crucial for the success of research initiatives, providing the necessary data to determine the safety and effectiveness of new interventions.

As a premedical student, my passion for research and medicine encouraged me to pursue my current role as a clinical research technician. Initially, I took this initiative as an opportunity to refine my clinical skills and cultivate effective teamwork and communication abilities, particularly my bedside manner. However, beyond the technical aspects of my role lies a profound opportunity to engage directly with study participants and glean invaluable perspectives into their motivations and experiences that drive them to participate in clinical studies. In the following paragraphs, I will share my observations on the diverse motivations behind participation in clinical trials that I found intriguing.

Nonetheless, it is essential to note that my reflections are based solely on my observations and interactions within a research organization. While they offer a window into the world of clinical research, they may not fully encapsulate the myriad experiences across the broader research community.

Understanding why individuals choose to participate in clinical research reveals a complex tapestry of motivations. Some volunteers are driven by altruistic motives, such as the desire to help others and contribute to the advancement of medical science. They recognize the potential impact their participation can have on improving health care for future generations.

For others, personal motivations play a significant role. Some participants seek access to cutting-edge treatments that are not yet available to the public, hoping to find solutions to their own health conditions or those of loved ones. Additionally, some volunteers view clinical studies as an opportunity to receive comprehensive medical care and monitoring, often at no cost.

Through my observation working in a clinical research setting for almost two years, I have also realized that many participants are regulars in clinical trials. It is not uncommon to see the same people participating in different studies over time. This pattern suggests that monetary compensation is a key motivator for many participants. For some, clinical trials provide a vital source of income, making it feasible for them to support themselves or their families. Understandably, the primary concern for many participants revolves around the timing of their compensation checks. Given that they are compensated for their time and willingness to undergo testing, it is natural for them to be focused on when they will receive their payments. This financial incentive often drives repeat participation, highlighting the diverse and sometimes pressing motivations behind volunteer engagement in clinical research.

As I prepare to begin my medical education, I find reflecting on my experiences as a clinical research technician essential, hence why I am writing this article. While I have honed technical skills such as phlebotomy and interpretation of ECGs and vital signs, my role as a technician has imparted an invaluable lesson: the importance of patient interactions and understanding their personal stories. One of a physician’s most crucial skills is building rapport with patients and gaining a deeper understanding of the life circumstances that influence their health. As I advance in my medical education and future career, I am committed to applying this lesson, fostering strong patient relationships, and appreciating each individual’s unique motivations and experiences.

To my fellow premedical students and aspiring medical professionals: embrace every opportunity to learn from your interactions with patients. These experiences are not just stepping stones but foundational elements that will shape your approach to patient care. Your journey in medicine will be enriched by the stories you hear, the compassion you show, and the understanding you develop. Remember, the heart of medicine lies not just in the science but in the human connections we build along the way.

Pouria Rostamiasrabadi is a premedical student.

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