Skip to content
  • About
  • Contact
  • Contribute
  • Book
  • Careers
  • Podcast
  • Recommended
  • Speaking
  • All
  • Physician
  • Practice
  • Policy
  • Finance
  • Conditions
  • .edu
  • Patient
  • Meds
  • Tech
  • Social
  • Video
    • All
    • Physician
    • Practice
    • Policy
    • Finance
    • Conditions
    • .edu
    • Patient
    • Meds
    • Tech
    • Social
    • Video
    • About
    • Contact
    • Contribute
    • Book
    • Careers
    • Podcast
    • Recommended
    • Speaking

The human element in clinical trials

Dr. Bodhibrata Banerjee
Physician
November 25, 2025
Share
Tweet
Share

I have often heard people speak of numerology, weaving destinies around digits. They say that behind every event in a person’s life lies the hidden hand of numbers. I do not know if such beliefs hold scientific truth. Yet, in medicine, numbers certainly matter. Numbers fill our trial registers, power our statistics, shape our protocols. In research, life is reduced to codes, columns, and counts.

As a medical student, the jargon of trials had felt almost glamorous: randomization, open label, blinding, matching. But residency revealed how quickly those shining words grow thorns. When I began my dissertation, I found myself thrust into the real machinery of a clinical trial. My guide taught me the rules: The patients and I were both to be “blinded.” Pills were sealed in identical containers, marked only by serial codes. Neither doctor nor patient knew which treatment was hidden inside. It was, as the experts said, a “double-blind study.”

At first, I felt an eagerness almost naïve. Each patient who consented brought the promise of science unfolding before me. I began calling them back, recording their symptoms, charting their progress. Patient One. Patient Two. Patient Three. And so it went (four, five, six), numbers accumulating like beads on a string.

Until I reached Patient Number Thirteen.

One morning, while scanning my list, I realized he had not returned even once. A knot of worry formed in my chest. My guide would surely ask about him. Irritated, I dialed the number in his file. A frail feminine voice answered. She was his wife.

I spoke with the impatience of a resident buried in deadlines: Why has he not come? Has he taken the medicines I gave him?

Her reply arrived like a slow wave of sorrow. His father had died. The family’s fields had drowned in flood. There were mouths to feed: two little daughters, a son too young to work. “He sold the medicines, Doctorsaab,” she whispered, ashamed. “You once told us they were worth two thousand rupees. With that money, he could buy rice for the children.”

I froze. My trial, my proforma, my protocol? What did they mean against the gnawing hunger of a family?

“But how does he bear the pain?” I asked, almost angrily.

“Doctorsaab,” she said softly, “there is no pain greater than watching your children starve. He swallows cheap painkillers, and somehow he goes on.”

Her voice broke, yet she thanked me through her tears: It is a big meherbani that you even called us. She did not know that my call was born of data points, not compassion.

The line disconnected, but her words remained.

For me, he was Patient Number Thirteen: an entry in a register, a code on a pill bottle. For her, he was husband, father, breadwinner, son. I could not relieve his disease, but unknowingly I had given him another kind of medicine: a currency against hunger, a weapon against poverty.

ADVERTISEMENT

Numbers matter, yes. They guide our science, anchor our statistics, clothe our arguments in evidence. But beyond the arithmetic of trials lie other numbers: the price of grain, the cost of survival, the count of hungry mouths. And sometimes, in the ledger of life, those outweigh the pain scales and p-values we hold so dear.

Patient Number Thirteen never came back to my clinic. Yet he has stayed with me, long after the trial ended.

Bodhibrata Banerjee is a rheumatology fellow in India.

Prev

Is direct primary care sustainable in a downturn?

November 25, 2025 Kevin 0
…

Kevin

Tagged as: Rheumatology

Post navigation

< Previous Post
Is direct primary care sustainable in a downturn?

ADVERTISEMENT

More by Dr. Bodhibrata Banerjee

  • The silent victories of medicine

    Dr. Bodhibrata Banerjee

Related Posts

  • Understanding why people participate in clinical trials

    Pouria Rostamiasrabadi
  • Why retail pharmacies are the future of diverse clinical trials

    Shelli Pavone
  • For medical students: 20 pearls to honor every clinical rotation

    Ton La, Jr., MD, JD
  • Be a human first and a doctor second

    Sarah Murad
  • The trials and tribulations of health care delivery

    Michelle Detka
  • Why clinical research is a powerful path for unmatched IMGs

    Dr. Khutaija Noor

More in Physician

  • The Silicon Valley primary care doctor shortage

    George F. Smith, MD
  • How relationships predict physician burnout risk

    Tomi Mitchell, MD
  • Preserving your sense of self as a doctor

    Camille C. Imbo, MD
  • The geometry of communication in medicine

    Patrick Hudson, MD
  • Why I became a pediatrician: a doctor’s story

    Jamie S. Hutton, MD
  • Is trauma surgery a dying field?

    Farshad Farnejad, MD
  • Most Popular

  • Past Week

    • Direct primary care in low-income markets

      Dana Y. Lujan, MBA | Policy
    • The Silicon Valley primary care doctor shortage

      George F. Smith, MD | Physician
    • Female athlete urine leakage: A urologist explains

      Martina Ambardjieva, MD, PhD | Conditions
    • AI in medical imaging: When algorithms block the view

      Gerald Kuo | Tech
    • Are you neurodivergent or just bored?

      Martha Rosenberg | Meds
    • The danger of dismantling DEI in medicine

      Jacquelyne Gaddy, MD | Physician
  • Past 6 Months

    • Why you should get your Lp(a) tested

      Monzur Morshed, MD and Kaysan Morshed | Conditions
    • Rebuilding the backbone of health care [PODCAST]

      The Podcast by KevinMD | Podcast
    • The dismantling of public health infrastructure

      Ronald L. Lindsay, MD | Physician
    • The flaw in the ACA’s physician ownership ban

      Luis Tumialán, MD | Policy
    • Systematic neglect of mental health

      Ronke Lawal | Tech
    • Silicon Valley’s primary care doctor shortage

      George F. Smith, MD | Physician
  • Recent Posts

    • The human element in clinical trials

      Dr. Bodhibrata Banerjee | Physician
    • Is direct primary care sustainable in a downturn?

      Dana Y. Lujan, MBA | Conditions
    • The Silicon Valley primary care doctor shortage

      George F. Smith, MD | Physician
    • Transforming patient fear into understanding through clear communication [PODCAST]

      The Podcast by KevinMD | Podcast
    • How movement improves pelvic floor function

      Martina Ambardjieva, MD, PhD | Conditions
    • How immigrant physicians solved a U.S. crisis

      Eram Alam, PhD | Conditions

Subscribe to KevinMD and never miss a story!

Get free updates delivered free to your inbox.


Find jobs at
Careers by KevinMD.com

Search thousands of physician, PA, NP, and CRNA jobs now.

Learn more

Leave a Comment

Founded in 2004 by Kevin Pho, MD, KevinMD.com is the web’s leading platform where physicians, advanced practitioners, nurses, medical students, and patients share their insight and tell their stories.

Social

  • Like on Facebook
  • Follow on Twitter
  • Connect on Linkedin
  • Subscribe on Youtube
  • Instagram

ADVERTISEMENT

ADVERTISEMENT

  • Most Popular

  • Past Week

    • Direct primary care in low-income markets

      Dana Y. Lujan, MBA | Policy
    • The Silicon Valley primary care doctor shortage

      George F. Smith, MD | Physician
    • Female athlete urine leakage: A urologist explains

      Martina Ambardjieva, MD, PhD | Conditions
    • AI in medical imaging: When algorithms block the view

      Gerald Kuo | Tech
    • Are you neurodivergent or just bored?

      Martha Rosenberg | Meds
    • The danger of dismantling DEI in medicine

      Jacquelyne Gaddy, MD | Physician
  • Past 6 Months

    • Why you should get your Lp(a) tested

      Monzur Morshed, MD and Kaysan Morshed | Conditions
    • Rebuilding the backbone of health care [PODCAST]

      The Podcast by KevinMD | Podcast
    • The dismantling of public health infrastructure

      Ronald L. Lindsay, MD | Physician
    • The flaw in the ACA’s physician ownership ban

      Luis Tumialán, MD | Policy
    • Systematic neglect of mental health

      Ronke Lawal | Tech
    • Silicon Valley’s primary care doctor shortage

      George F. Smith, MD | Physician
  • Recent Posts

    • The human element in clinical trials

      Dr. Bodhibrata Banerjee | Physician
    • Is direct primary care sustainable in a downturn?

      Dana Y. Lujan, MBA | Conditions
    • The Silicon Valley primary care doctor shortage

      George F. Smith, MD | Physician
    • Transforming patient fear into understanding through clear communication [PODCAST]

      The Podcast by KevinMD | Podcast
    • How movement improves pelvic floor function

      Martina Ambardjieva, MD, PhD | Conditions
    • How immigrant physicians solved a U.S. crisis

      Eram Alam, PhD | Conditions

MedPage Today Professional

An Everyday Health Property Medpage Today
  • Terms of Use | Disclaimer
  • Privacy Policy
  • DMCA Policy
All Content © KevinMD, LLC
Site by Outthink Group

Leave a Comment

Comments are moderated before they are published. Please read the comment policy.

Loading Comments...