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The human element in clinical trials

Dr. Bodhibrata Banerjee
Physician
November 25, 2025
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I have often heard people speak of numerology, weaving destinies around digits. They say that behind every event in a person’s life lies the hidden hand of numbers. I do not know if such beliefs hold scientific truth. Yet, in medicine, numbers certainly matter. Numbers fill our trial registers, power our statistics, shape our protocols. In research, life is reduced to codes, columns, and counts.

As a medical student, the jargon of trials had felt almost glamorous: randomization, open label, blinding, matching. But residency revealed how quickly those shining words grow thorns. When I began my dissertation, I found myself thrust into the real machinery of a clinical trial. My guide taught me the rules: The patients and I were both to be “blinded.” Pills were sealed in identical containers, marked only by serial codes. Neither doctor nor patient knew which treatment was hidden inside. It was, as the experts said, a “double-blind study.”

At first, I felt an eagerness almost naïve. Each patient who consented brought the promise of science unfolding before me. I began calling them back, recording their symptoms, charting their progress. Patient One. Patient Two. Patient Three. And so it went (four, five, six), numbers accumulating like beads on a string.

Until I reached Patient Number Thirteen.

One morning, while scanning my list, I realized he had not returned even once. A knot of worry formed in my chest. My guide would surely ask about him. Irritated, I dialed the number in his file. A frail feminine voice answered. She was his wife.

I spoke with the impatience of a resident buried in deadlines: Why has he not come? Has he taken the medicines I gave him?

Her reply arrived like a slow wave of sorrow. His father had died. The family’s fields had drowned in flood. There were mouths to feed: two little daughters, a son too young to work. “He sold the medicines, Doctorsaab,” she whispered, ashamed. “You once told us they were worth two thousand rupees. With that money, he could buy rice for the children.”

I froze. My trial, my proforma, my protocol? What did they mean against the gnawing hunger of a family?

“But how does he bear the pain?” I asked, almost angrily.

“Doctorsaab,” she said softly, “there is no pain greater than watching your children starve. He swallows cheap painkillers, and somehow he goes on.”

Her voice broke, yet she thanked me through her tears: It is a big meherbani that you even called us. She did not know that my call was born of data points, not compassion.

The line disconnected, but her words remained.

For me, he was Patient Number Thirteen: an entry in a register, a code on a pill bottle. For her, he was husband, father, breadwinner, son. I could not relieve his disease, but unknowingly I had given him another kind of medicine: a currency against hunger, a weapon against poverty.

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Numbers matter, yes. They guide our science, anchor our statistics, clothe our arguments in evidence. But beyond the arithmetic of trials lie other numbers: the price of grain, the cost of survival, the count of hungry mouths. And sometimes, in the ledger of life, those outweigh the pain scales and p-values we hold so dear.

Patient Number Thirteen never came back to my clinic. Yet he has stayed with me, long after the trial ended.

Bodhibrata Banerjee is a rheumatology fellow in India.

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