Why progression independent of relapse activity is the silent driver of disability in multiple sclerosis
For too long, multiple sclerosis (MS) has been described with an air of quiet fatalism, a chronic, debilitating disease managed primarily by reducing relapses, but not fully addressed in terms of its continuous, underlying disability progression. This smoldering process often is not easily visible because of its progressive nature. Patients are told to manage expectations, while clinicians are taught to define success by the absence of magnetic resonance imaging (MRI) …











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