Why “eat less, move more” fails for midlife weight loss

Clinicians often notice a frustrating pattern: Women in midlife follow standard weight-loss advice, eat less and move more, yet see little progress. Calories are reduced, exercise increases, and still the scale barely moves. This is often blamed on motivation, discipline, or compliance. But in many cases, the real issue is not behavior. It’s physiology.

Perimenopause and menopause are not simply estrogen-deficient states; they are states of altered signaling, altered tissue responsiveness, …

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Why “eat less, move more” fails for midlife weight loss