Robert Centor suggests that the zeal to lower hemoglobin A1c’s below 7 is partly responsible for the Avandia controversy:
His point, on which I concur, states that our efforts to lower HgbA1c stimulated our willingness to try another drug to reach the magic number. Perhaps the zeal for lowering HgbA1c to below 7 stimulates us to use a second or third drug. Perhaps if we had a more realistic goal of 8 we would have less’glitazone’ use, and thus fewer bad outcomes.
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