GLP-1 weight regain: Why stopping medication leads to weight return

Stopping a GLP-1 abruptly and expecting maintenance of weight loss is not realistic. Even replacing it with a standard “eat less, move more” plan is not sufficient as it ignores what we know about hunger regulation and metabolic adaptation. A reduced-calorie diet and 30 minutes of daily walking, while helpful, are rarely sufficient to overcome the physiological forces defending prior weight.

Weight maintenance after significant loss requires managing cravings, psychological hunger …

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GLP-1 weight regain: Why stopping medication leads to weight return