The Dozortsev-Diamond paradigm: Is progesterone the true ovulation trigger?
Every reproductive endocrinologist knows that ovulation is triggered by estradiol. In our textbooks, the sequence is clear: Estradiol rises, triggers an LH surge, and ovulation follows, culminating in the formation of a corpus luteum, which produces progesterone to support implantation and pregnancy. It is straightforward and reassuringly precise, and it forms the backbone of our clinical practice.
Yet, from the very beginning of training, we are instructed to use artificial ovulation …
The Dozortsev-Diamond paradigm: Is progesterone the true ovulation trigger?
