The recent inclusion of moral injury as a Z code in the DSM marks a moment for mental health. Z codes place a diagnosis in an environmental or psychosocial context. After years of advocacy from clinicians and veterans, moral injury has entered our clinical lexicon. This action validates the linkage between our embeddedness in the world and our individual struggles, from soldiers and first responders to physicians navigating a broken system. This framework allows for a more granular understanding of the concept’s origins. While the code is a vital refinement, it doesn’t automatically equip us to understand the underlying mechanism, which is necessary to effectively heal it. To do that, we must look past the symptoms of trauma and guilt to the debilitating engine at its core: toxic shame.
A biological definition for moral injury
The work of psychologist Silvan Tomkins provides the clearest lens for this. He defined shame not as a social embarrassment, but as a biological affect: Shame is the impediment to our ongoing interest. This formulation has its origins in our neuroanatomy and chemistry. Shame, when understood at this level, is not psychological but physiological. It is the abrupt slowing of dopamine via the interaction of the habenula-amygdala-hippocampus axis and the VTA. However, this psychic pain arises so swiftly that it enters our consciousness and is immediately assigned a negative cognitive meaning. “Interest,” grounded in the flow of dopamine, is our life force: our innate curiosity and drive to connect, learn, and engage with the world. Shame is the physiological braking system that halts this drive. It’s the experience of reaching for a connection only to have it severed, triggering an immediate, hardly noticeable pang of pain to a full-body response of withdrawal and collapse. We recognized that shame, as seen in moral injury, does not have to be a grand, overarching shattering of the self. When severe enough, it can and does either exacerbate other conditions or can be the impetus to unleash dormant predispositions.
The cognitions associated with the event mainly follow one of two paths. The first is when the belief that “I am a good person” is punctured, replaced by an identity of being “tainted” or “broken.” For example, a soldier responsible for the death of an innocent family sees their self-concept shattered. This severs the connection to oneself, impeding any “interest” in one’s future and triggering a vicious cycle. The second, and perhaps more common path, occurs when one’s faith in a system is betrayed. Moral injury is a shame event. The transgressive act (whether performed, witnessed, failed to prevent, or suffered as a consequence of others’ actions) interrupts the individual’s connection to their own sense of goodness or their faith in the goodness of others. This can manifest in several ways:
- A soldier who strives to uphold the oath of honor, duty, and integrity is given a clear, unlawful order.
- A physician bound by the principle of nonmaleficence must comply with an administrative directive to taper all patients off opiates.
- A business marketer is asked to actively contradict clear adverse safety data.
- A patient having faith in the health care system is denied chemotherapy by their insurance.
Some of the consequences are as follows:
- The person withdraws from others, anticipating judgment or not knowing where to turn or whom to trust. Their “interest” in community is blocked.
- The person’s moral map is destroyed. Belief in a just world or trusted institutions is severely damaged, and this blocks the “interest” needed to engage meaningfully with life.
The injury can be akin to a flesh wound or an amputation, the latter being the realization that what happened was not right and, at some level, calls into question one’s faith in the order of things or in the self.
From diagnosis to healing: a shame-informed approach
With moral injury included in the Z codes, used to identify psychosocial and environmental factors, our challenge shifts from recognition to effective treatment. A shame-informed approach can clarify the phenomena. We can further refine the picture by understanding guilt (“I did a bad thing”) as the cognitive story we attach to the raw physiology of shame. This story includes a learned fear of punishment or negative consequences. Therefore, for those whose injury is viewed as a personal failure, our clinical focus turns to re-connection, the direct antidote to shame’s isolating power.
- Cultivate self-compassion: The first connection to repair is with the self. Interventions that help patients meet their self-loathing with kindness rather than fighting it are paramount. This calms the shame-driven threat response and creates internal safety.
- Facilitate witnessing in a safe community: Shame is mitigated by its exposure in a compassionate environment. Therapeutic groups, peer support, and a strong clinical alliance provide the context where the story can be told without condemnation, dissolving the need to hide.
For the injury of externalized betrayal (“the system is corrupt”): The work begins with validating the person’s anger and grief, affirming their perception of injustice. This often involves channeling that energy into constructive action, which restores a sense of agency.
Both paths converge on the need for a safe community, where the story can be told without condemnation. Ultimately, these actions help restore the flow of dopamine. Healing doesn’t mean erasing the past, but building a new, more complex identity that can hold the reality of the moral injury, whether a personal transgression or a profound betrayal. The new DSM Z code is progress, and it starts to give us the language to see and name the wound. But we can do better; we can become fluent in the language of shame. By understanding moral injury as the damaging “impediment to interest” it is, we can offer our patients a path back from trauma. Tomkins: “Interest makes the possible, possible.”
Brian Lynch is a family physician.



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