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Rethinking neuroplasticity and mental health in psychiatry

Farid Sabet-Sharghi, MD
Conditions and Diseases
June 26, 2026
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Every week, a familiar reflection settles into the corners of my mind as I look at my office desk. As a practicing psychiatrist, my days are spent navigating a gentle but persistent paradox. On one hand, my workspace is increasingly filled with paperwork: diagnostic standardizations, complex neuropsychological testing matrices, and formal institutional accommodation forms designed to categorize human behavior into neat, permanent columns. On the other hand, sitting across from me is the actual, living reality of human suffering and resilience, a reality that is fluid, deeply personal, and entirely resistant to being reduced to a static circuit diagram.

We seem to be living through an era dominated by the absolute hegemony of the neuroscience revolution. In modern psychiatry and broader public discourse, the brain scan has inadvertently become our ultimate arbiter of truth. If a specific behavior correlates with an active amygdala or shows a slight lag in prefrontal cortex development, it is often treated as an immutable, hardwired reality. There is a quiet tendency to weaponize these biological descriptions, forging a pessimistic view of human nature that frames our daily struggles as structurally unchangeable.

I recently ran across an extraordinary essay by UC Berkeley neuroscientist Tara Raam titled Understanding Neuroscience and Human Nature Through a Historical Lens. Reading her words felt like holding up a mirror to the exact professional conflicts I have wrestled with over the years. She beautifully articulates the precise flaw in how we digest modern science, observing that when brain imaging studies reveal neural patterns underlying our lower nature, such findings can seem to imply finality, making these aspects appear permanent and unchangeable.

This supposed finality is something I find myself reflecting on daily in clinical practice. When we look at conditions like anxiety, depression, or ADHD and treat them as fixed deficits, we miss a larger truth. In my own clinical framework, I tend to view these challenges not as absolute structural failures, but rather as biopsychosocial propensities. They are innate vulnerabilities and unique variations in how a brain interacts with its environment. While they undeniably pose significant barriers to the tasks of modern life, they are also temperaments that can be actively managed, integrated, and frequently leveraged into profound strengths like creativity, deep focus, and dynamic problem solving.

The essay exposes the shaky foundation upon which our biological determinism rests by highlighting a massive sampling bias in modern research. The vast majority of our universal neuroscientific truths are derived from Western, Educated, Industrialized, Rich, and Democratic populations. What we are calling human nature in our medical journals is frequently just a localized snapshot of how a brain adapts to a very specific, competitive socio-economic milieu. As the article insightfully notes, rather than revealing timeless truths about fixed human nature, these scans may simply be showing us how brains adapt to particular social milieus, acting as mirrors reflecting back the cultures that produced them.

This shift in perspective is something we might want to invite back into modern medicine. The brain is an organ of pure adaptation, possessing a breathtaking degree of neuroplasticity that continuously reshapes its physical architecture in response to culture, habit, lifestyle design, and intentional practice. Science is inherently descriptive, telling us what is happening right now under very specific parameters. It captures our species in a state of collective adolescence, turbulent and still learning how to coordinate. However, science cannot completely dictate what we ought to be, nor can it map the absolute ceiling of human potential.

If we continue to treat every neuroscientific finding as a permanent boundary line, we risk teaching individuals to accommodate their limitations rather than master their temperaments. We risk setting up young adults for a profound shock when they leave the educational bubble for a global economy that requires resilience and adaptability rather than systemic safety nets.

Our current biological snapshots do not constrain our future. Human nature is a vast spectrum of neurodiversity and possibility. As we actively evolve our families, our schools, and our clinical practices toward deeper connection and mutual support, our brains will inevitably adapt in response. The scan is a wonderful map of where we are standing today, but it was never meant to be the final destination.

Farid Sabet-Sharghi is a psychiatrist.

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